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G Protein-Coupled Inwardly-Rectifying Potassium Channels (GIRK channels) are channels found in the brain that play a crucial role in the inhibitory effects of neurotransmitters.

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.

G-protein-gated inwardly rectifying K + (GIRK) channels play a key role in maintaining resting membrane potential, cell excitability and inhibitory neurotransmission.

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